Sickle cell disease is a genetic disorder characterized by the presence of abnormal hemoglobin, leading to various complications, including vaso-occlusive crises and organ damage. While much research has focused on the homozygous hemoglobin SS genotype, less is known about the heterogeneous hemoglobin SC genotype (HbSC), particularly in adults. This case report details the presentation, clinical course, and management of a 27-year-old African American man with HbSC sickle cell disease, who presented with severe acute encephalopathy and multifocal acute ischemic stroke and had a positive neurological outcome due to early red blood cell exchange transfusion. The case underscores the need for vigilant clinical care considerations into the unique challenges for adults with HbSC disease.

Biodegradable temporizing matrices (BTMs) are temporary, biocompatible, and resorbable scaffolds designed to temporarily occupy a defect site, facilitating tissue regeneration and neodermal growth in a surgical wound or defect site while minimizing the need for extensive tissue transfers. Spiradenomas are mostly benign skin tumors developing from sweat gland cells that typically require surgical excision as treatment, which can result in scarring and functional impairment, especially in functional joint areas like the ankle. While the application of BTMs in small- to moderate-sized defects resulting from malignant resections in functionally critical areas has shown promising results in preliminary studies, the use of BTM for functional reconstruction is an emerging concept that needs to be further studied. This case report presents the successful application of a BTM in the reconstruction of a soft tissue defect following wide local excision of a spiradenoma on the right ankle of a 64-year-old man, demonstrating the value of these matrices as an essential reconstructive tool in the management of soft tissue defects following malignant resections.

Bullous pemphigoid (BP) is a rare autoimmune skin disorder most commonly seen in older adults. It is marked by subepidermal blistering due to autoantibodies targeting hemidesmosomal proteins. While often idiopathic, BP has occasionally been linked to internal malignancies. We present the case of a 77-year-old man whose diagnosis of BP led to the detection of invasive colorectal adenocarcinoma. This case highlights the need for malignancy screening in patients with atypical dermatologic presentations and systemic symptoms.

Burn injuries impose a significant global health burden, particularly in low- and middle-income countries where access to surgical interventions is limited. In such settings, supportive measures, especially nutrition, play a central role in recovery. We report the case of a 30-year-old man with ~70% total body surface area scald burns, including superficial and deep partial-thickness injuries. On admission, he was hemodynamically stable but at high risk of malnutrition. Multidisciplinary care included fluid resuscitation, antimicrobial dressings, antibiotics, and early nutrition. Energy and protein goals were set at 3400 to 3800 kcal/day and 153 to 212 g/day, respectively. By day 4, oral intake achieved ~3500 to 3700 kcal/day and 178 to 205 g protein/day. The patient showed rapid healing of superficial burns (50%–55% total body surface area by postburn day 19) and complete wound closure at 5 months, without grafting. One-year follow-up revealed no major complications, although expected scarring and contractures occurred. In conclusion, aggressive nutritional care potentially achieved favorable outcomes in this burn patient.