2024 The efficacy and safety of botulinum toxin epicardial fat injection to prevent postoperative atrial fibrillation in patients undergoing cardiac surgery: a meta-analysis of randomized controlled trials

Abstract

Postoperative atrial fibrillation (POAF) is prevalent in about 30% to 60% of patients undergoing cardiac surgery, leading to worse outcomes. Botulinum toxin type A (BTX) epicardial injection has been proposed to prevent POAF by impairing cholinergic signaling. 


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Faculty credentials/disclosure 

Dr. Saleh is in the Faculty of Medicine at the Hashemite University, Zarqa, Jordan; Dr. Kambalapall and Dr. Abdelazeem are internists at McLaren Health Care, Michigan State University; and Dr. AlBarakat is in the Faculty of Medicine at Jordan University of Science and Technology, Irbid, Jordan. Mohamed Abuelazm, Ibrahim Gowail, and Abdelrahman Mahmoud are MBBCh candidates at the Faculty of Medicine, Tanta University, Tanta, Egypt. The authors and planner for this educational activity have no relevant financial relationship(s) to disclose with ineligible companies whose primary business is producing, marketing, selling, re-selling, or distributing health care products used by or on patients. 

Process

Click the "add to cart/begin" button, pay any relevant fee, take the quiz, complete the evaluation, and claim your CME credit.  You must achieve 100% on the quiz with unlimited attempts available.

  • By completing this process, you are attesting that you have read the journal article.
  • By claiming ABIM MOC credit you are providing permission to have your data uploaded into the Accreditation Council for Continuing Medical Education (ACCME) system for transfer to the American Board of Internal Medicine (ABIM).

You will need to verify that your profile contains your correct birthdate (mm/dd) and ABIM diplomate number. For your convenience, please click here to verify your ABIM diplomate number. 

Expiration date:

Credit eligibility for this article is set to expire on March 1, 2025.

Target Audience

Cardiologists and cardiac surgeons

Learning Objectives

After completing the article, the learner should be able to:

  • Describe the prevalence and clinical implications of postoperative atrial fibrillation in patients undergoing cardiac surgery.
  • Evaluate the efficacy and safety of botulinum toxin epicardial fat pad injection as a prophylactic measure against postoperative atrial fibrillation based on the findings from randomized controlled trials.
  • Identify potential factors and cellular mechanisms influencing the development of postoperative atrial fibrillation and recognize the need for further research in this area, including potential combination therapies and dosage considerations for botulinum toxin type A injection.
Course summary
Available credit: 
  • 1.00 American Board of Internal Medicine (ABIM) MOC Part 2
    Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.00 MOC points in the American Board of Medicine’s (ABIM) Maintenance of Certification (MOC) program. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.
  • 1.00 American Board of Surgery (ABS) Accredited CME
    Successful completion of this CME activity, which includes participation in the evaluation component, enables the learner to earn credit toward the CME Medical Knowledge of the American Board of Surgery's Continuous Certification program. It is the CME activity provider's responsibility to submit learner completion information to ACCME for the purpose of granting ABS credit.
  • 1.00 AMA PRA Category 1 Credit™
    The A. Webb Roberts Center for Continuing Medical Education of Baylor Scott & White Health is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
  • 1.00 Attendance
Course opens: 
03/01/2024
Course expires: 
03/01/2025
Cost:
$25.00
Rating: 
0

  • Mohamed Abuelazm, MBBCh candidate* - Faculty of Medicine, Tanta University, Tanta, Egypt 

  • Othman Saleh, MD* - Faculty of Medicine, The Hashemite University, Zarqa, Jordan 

  • Soumya Kambalapalli, MD - Department of Internal Medicine, McLaren Health Care, Flint, Michigan, USA and Department of Internal Medicine, Michigan State University, East Lansing, Michigan, USA 

  • Majd M. Albarakat, MD - Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan 

  • Ibrahim Gowaily, MBBCh candidate - Faculty of Medicine, Tanta University, Tanta, Egypt 

  • Abdelrahman Mahmoud, MBBCh candidate - Faculty of Medicine, Minia University, Minia, Egypt 

  • Basel Abdelazeem, MD - Department of Cardiology, West Virginia University, Morgantown, West Virginia, USA 

*Both authors have equal contributions and are co–first authors. 

Corresponding author:

  • Majd M. AlBarkat, MD - Jordan University of Science and Technology

Accreditation

The A. Webb Roberts Center for Continuing Medical Education of Baylor Scott & White Health is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Designation

AMA PRA Category 1 Credit™

The A. Webb Roberts Center for Continuing Medical Education of Baylor Scott & White Health designates this Journal-based CME activity for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

ABS CC

Successful completion of this CME activity enables the learner to earn credit toward the CME requirement of the American Board of Surgery’s Continuous Certification program. It is the CME activity provider's responsibility to submit learner completion information to ACCME for the purpose of granting ABS credit.

ABIM MOC

 Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.0 MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

 

Available Credit

  • 1.00 American Board of Internal Medicine (ABIM) MOC Part 2
    Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.00 MOC points in the American Board of Medicine’s (ABIM) Maintenance of Certification (MOC) program. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.
  • 1.00 American Board of Surgery (ABS) Accredited CME
    Successful completion of this CME activity, which includes participation in the evaluation component, enables the learner to earn credit toward the CME Medical Knowledge of the American Board of Surgery's Continuous Certification program. It is the CME activity provider's responsibility to submit learner completion information to ACCME for the purpose of granting ABS credit.
  • 1.00 AMA PRA Category 1 Credit™
    The A. Webb Roberts Center for Continuing Medical Education of Baylor Scott & White Health is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
  • 1.00 Attendance

Price

Cost:
$25.00
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