Role of endothelial cell receptors in the context of SARS-CoV-2 infections (COVID-19)

Abstract

Endothelial cell (EC) dysfunction contributes to COVID-19–associated vascular inflammation and coagulopathy, and the angioten-sin-converting enzyme 2 (ACE2) receptor plays a role in EC dysfunction in COVID-19. To expand the understanding of the role of the ACE2 receptor relative to EC dysfunction, this review addresses (1) tissue distribution of the ACE2 protein and its mRNA expression in humans, (2) susceptibility of the capillary ECs to SARS-CoV-2 infection, and (3) the role of EC dysfunction relevant to ACE2 and nuclear factor-jB in COVID-19.

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Faculty credentials/disclosure 

Dr. Jun Zhang received his MD and MS in human pathology and has worked as a research pharmacologist for approximately 30 years. Dr. Kristen M. Tecson received her PhD in statistical science and has worked in the field of cardiovascular research for the past 5 years. Dr. Peter A. McCullough (MD, MPH) is a practicing cardiologist and an internationally recognized authority on the role of chronic kidney disease as a cardiovascular risk state. The authors and planner report no conflicts of interest. This work was partially funded by the Baylor Health Care System Foundation.

Process

Click the take course button, pay any relevant fee, take the quiz, complete the evaluation, and claim your CME credit.  You must achieve 100% on the quiz with unlimited attempts available.

  • By completing this process, you are attesting that you have read the journal article.
  • By claiming ABIM MOC credit you are providing permission to have your data uploaded into the Accreditation Council for Continuing Medical Education (ACCME) system for transfer to the American Board of Internal Medicine (ABIM).

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Expiration date

Credit eligibility for this article is set to expire on March 1, 2023.

Target Audience

All physicians

Learning Objectives

After completing the article, the learner should be able to:

  • Recognize how the susceptibility of capillary endothelial cells contributes to widespread pulmonary and endo-organ injury in the setting of SARS-CoV-2 infection
  • Discuss how new and preexisting endothelial cell dysfunction and the crosstalk of pathways between the angiotensin-converting enzyme 2 receptor and other endothelial cell receptors account for the intensity and extent of systemic manifestations in COVID-19
Course summary
Available credit: 
  • 1.00 American Board of Internal Medicine (ABIM) MOC Part 2 Medical Knowledge
    Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.00 Medical Knowledge points in the American Board of Medicine’s (ABIM) Maintenance of Certification (MOC) program. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.
  • 1.00 AMA PRA Category 1 Credit™
    The A. Webb Roberts Center for Continuing Medical Education of Baylor Scott & White Health is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
  • 1.00 Attendance
Course opens: 
03/01/2021
Course expires: 
03/01/2023
Cost:
$25.00
Rating: 
0

Accreditation

The A. Webb Roberts Center for Continuing Medical Education of Baylor Scott & White Health is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Designation

AMA PRA Category 1 Credit

The A. Webb Roberts Center for Continuing Medical Education of Baylor Scott & White Health designates this Journal-based CME activity for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

American Board of Internal Medicine Maintenance of Certification (MOC)

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1 Medical Knowledge MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

Available Credit

  • 1.00 American Board of Internal Medicine (ABIM) MOC Part 2 Medical Knowledge
    Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.00 Medical Knowledge points in the American Board of Medicine’s (ABIM) Maintenance of Certification (MOC) program. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.
  • 1.00 AMA PRA Category 1 Credit™
    The A. Webb Roberts Center for Continuing Medical Education of Baylor Scott & White Health is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
  • 1.00 Attendance

Price

Cost:
$25.00
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