Role of endothelial cell receptors in the context of SARS-CoV-2 infections (COVID-19)
Abstract
Endothelial cell (EC) dysfunction contributes to COVID-19–associated vascular inflammation and coagulopathy, and the angioten-sin-converting enzyme 2 (ACE2) receptor plays a role in EC dysfunction in COVID-19. To expand the understanding of the role of the ACE2 receptor relative to EC dysfunction, this review addresses (1) tissue distribution of the ACE2 protein and its mRNA expression in humans, (2) susceptibility of the capillary ECs to SARS-CoV-2 infection, and (3) the role of EC dysfunction relevant to ACE2 and nuclear factor-jB in COVID-19.
Faculty credentials/disclosure
Dr. Jun Zhang received his MD and MS in human pathology and has worked as a research pharmacologist for approximately 30 years. Dr. Kristen M. Tecson received her PhD in statistical science and has worked in the field of cardiovascular research for the past 5 years. Dr. Peter A. McCullough (MD, MPH) is a practicing cardiologist and an internationally recognized authority on the role of chronic kidney disease as a cardiovascular risk state. The authors and planner report no conflicts of interest. This work was partially funded by the Baylor Health Care System Foundation.
Process
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Expiration date
Credit eligibility for this article is set to expire on March 1, 2023.
Target Audience
All physicians
Learning Objectives
After completing the article, the learner should be able to:
- Recognize how the susceptibility of capillary endothelial cells contributes to widespread pulmonary and endo-organ injury in the setting of SARS-CoV-2 infection
- Discuss how new and preexisting endothelial cell dysfunction and the crosstalk of pathways between the angiotensin-converting enzyme 2 receptor and other endothelial cell receptors account for the intensity and extent of systemic manifestations in COVID-19
Accreditation
The A. Webb Roberts Center for Continuing Medical Education of Baylor Scott & White Health is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
Designation
AMA PRA Category 1 Credit™
The A. Webb Roberts Center for Continuing Medical Education of Baylor Scott & White Health designates this Journal-based CME activity for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
American Board of Internal Medicine Maintenance of Certification (MOC)
Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1 MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.
Available Credit
- 1.00 American Board of Internal Medicine (ABIM) MOC Part 2Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.00 MOC points in the American Board of Medicine’s (ABIM) Maintenance of Certification (MOC) program. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.
- 1.00 AMA PRA Category 1 Credit™The A. Webb Roberts Center for Continuing Medical Education of Baylor Scott & White Health is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
- 1.00 Attendance