2025 Clinician Corner - Histologic changes of basal cell carcinomas during vismodegib treatment
We report a case of a 63-year-old man with a history of numerous basal cell carcinomas (BCCs) on vismodegib who developed a pink subcutaneous nodule that was thought to be either a BCC or an epidermal inclusion cyst. Sections displayed a dome-shaped lesion composed of large dermal nodules of epithelioid cells with variable cytology. Some of the dermal nodules demonstrated squamatization of the epithelioid cells while others had a predominantly basaloid phenotype. Central necrosis was present in the majority of the large dermal nodules, but the lesion did not stain with CK7 or CK20, helping to rule out internal metastases. The epithelial nodules stained strongly with pancytokeratin (AE1/AE3), p40, and stained lightly with BCL-2, supporting the diagnosis of BCC. However, Ber-EP4 being negative and the presence of significant squamatization suggest vismodegib can alter both the histological and immunophenotype of BCCs. This phenomenon has rarely been reported in literature. 
Category
  • BUMC Proceedings
Format
  • Journal
Credits
  • 1.00 American Board of Internal Medicine (ABIM) MOC Part 2
  • 1.00 American Board of Surgery (ABS) Accredited CME
  • 1.00 AMA PRA Category 1 Credit™
  • 1.00 Attendance
Cost $25.00
2025 Clinician Corner - Urrets-Zavalia syndrome and secondary acute angle-closure glaucoma induced by implantable collamer lens
Implantable collamer lenses (ICL) have revolutionized the management of high refractive errors, yet they present unique challenges. We present a case of a fixed and dilated atonic pupil following acute-angle closure glaucoma from pupillary block after ICL implantation, known as Urrets-Zavalia syndrome. A 39-year-old woman developed acute ocular pain and headaches after surgery, leading to elevated intraocular pressure and subsequent complications necessitating ICL removal. This case highlights the need for prompt identification and management of elevated intraocular pressure to prevent irreversible complications such as Urrets-Zavalia syndrome following ICL implantation.
Category
  • BUMC Proceedings
Format
  • Journal
Credits
  • 1.00 American Board of Internal Medicine (ABIM) MOC Part 2
  • 1.00 AMA PRA Category 1 Credit™
  • 1.00 Attendance
Cost $25.00
2025 Clinician Corner - Amaurosis fugax in Takayasu arteritis mimicking migraine with visual aura
Takayasu arteritis is a rare vasculitis commonly seen in young women. Amaurosis fugax and headache are visual presentations of Takayasu arteritis. Migraine with visual aura is a common condition affecting young women, and differentiating migraine from Takayasu presenting with visual symptoms and headache can be challenging. We present a case of a young woman initially misdiagnosed with migraine with aura, who was later found to have Amaurosis fugax as an early manifestation of Takayasu arteritis.
Category
  • BUMC Proceedings
Format
  • Journal
Credits
  • 1.00 American Board of Internal Medicine (ABIM) MOC Part 2
  • 1.00 AMA PRA Category 1 Credit™
  • 1.00 Attendance
Cost $25.00
2025 Clinician Corner - Aceruloplasminemia as a rare hereditary disease: four case reports in a single center
Aceruloplasminemia, which is a very rare iron metabolism disorder, may present with extremely nonspecific complaints, and disease screening should be considered, especially in patients with consanguineous marriages. We share four cases diagnosed with aceruloplasminemia and their characteristics. The first three cases were related to each other and have consanguineous marriages in their family history. Our first and fourth cases were diagnosed with aceruloplasminemia upon detecting hypochromic microcytic anemia, low transferrin saturation, and a high ferritin level in the examinations performed after a nonspecific complaint such as fatigue. Even though the second and third cases had no complaints, they were diagnosed during screening tests because they were relatives of the first case.
Category
  • BUMC Proceedings
Format
  • Journal
Credits
  • 1.00 American Board of Internal Medicine (ABIM) MOC Part 2
  • 1.00 AMA PRA Category 1 Credit™
  • 1.00 Attendance
Cost $25.00
Infant CPR & Safety: Grapevine (In-Person Patient Class)
Our CPR Safety class is designed for anyone responsible for the care and safety of an infant. Come gain CPR skills and safety knowledge to childproof your home and prevent accidents. Each person must register individually for a space in this class.
Category
  • Health and Wellness
Format
  • In-Person
Credits
Cost $35.00
Newborn Care Online: Dallas (Online Patient Course)
Because the best birth is a supportive and informed birth, we have moved our award-winning new parent education classes to a virtual platform. Please join us from the safety and comfort of your own home and enjoy the same exclusive childbirth classes taught by experienced and credentialed educators. This class is perfect for expecting parents wondering what happens AFTER the baby comes. What's normal? Is baby pooping enough? What should I look for?
Category
  • Pediatric Care
Format
  • Online
Credits
Cost $50.00
Baby Wearing 101: Grapevine (In-Person Patient Class)
Join our fun interactive learn to Babywear class! In our small group setting, you’ll get hands-on experience discovering different carries types and finding the perfect fit for you and your baby. We’ll cover essential safety guidelines to ensure your little one’s comfort and security, delve into how babywearing supports healthy development, and explore the numerous benefits of keeping your baby close. Get ready to connect, learn, and enjoy the wonderful world of babywearing!
Category
  • Baby Care Classes
  • Pediatric Care
Format
  • In-Person
Credits
Cost $30.00
Breastfeeding Class: College Station (In-Person Patient Class)
This class for expectant parents focuses on the joys and common concerns of breastfeeding. Information includes the benefits for mothers and babies, initiating feedings, maintaining a milk supply and other practical considerations. Discussion includes combining breastfeeding and working and expression and storage of breast milk. Primary support persons are encouraged to attend.
Category
  • Pediatric Care
  • Women's Health
Format
  • In-Person
Credits
Cost $0.00
Clase de parto en línea: College Station (Online Patient Course)
Aprenda sobre el parto desde la comodidad de su hogar. No todas las familias son capaces de asistir a clases de educación paternales en persona, mientras que otros aprenden mejor con una clase de estudio. Esta instrucción interactiva basada en web, contiene ilustraciones animadas, videos y juegos para hacer el aprendizaje fácil y divertido. Una invitación al curso en línea le dará a usted dentro de 5 días hábiles después de haber completado el proceso de registro.
Category
  • Pediatric Care
  • Women's Health
Format
  • Online
  • Spanish
Credits
Cost $0.00
Cesarean Online Class: College Station (Online Patient Course)
Sometimes a planned cesarean is a necessary surgical birth option for a healthy mom and a healthy baby. Becoming informed and prepared will help you gain understanding and help you make good choices. Learn about what to expect during your hospital stay and how to have a good recovery process when you return home. This FREE online class is well worth watching as you get ready for your baby's arrival.
Category
  • Pediatric Care
  • Women's Health
Format
  • Online
Credits
Cost $0.00

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